WEDNESDAY, March 30, 2022 (HealthDay News) — Vaccination against COVID-19 is not associated with an increased risk of adverse perinatal outcomes, according to a large Canadian study published online March 24 in the Journal of the American Medical Association.
Deshayne B. Fell, Ph.D., of the University of Ottawa in Canada, and colleagues examined peripartum outcomes after COVID-19 vaccination during pregnancy in a population-based retrospective cohort study conducted in Ontario, Canada. All births between December 14, 2020 and September 30, 2021 were included, with a total of 97,590 individuals.
The researchers found that 22,660 people (23%) had received at least one dose of COVID-19 vaccine during pregnancy (99.8% had received an mRNA vaccine). Comparing people vaccinated during and after pregnancy (44,815 people), the risks of postpartum hemorrhage, chorioamnionitis, cesarean delivery, admission to neonatal intensive care unit or low Apgar score were not significantly increased. When compared to people who did not receive the COVID-19 vaccination at any time (30,115 people), the findings were qualitatively similar.
“Interpretations did not change when the comparison group was people vaccinated after pregnancy (who were more similar to those vaccinated during pregnancy in baseline characteristics, but had a different pregnancy schedule) or people who had not received a COVID-19 vaccine at any time by the end of September 2021 (who were more similar to those vaccinated during pregnancy in terms of pregnancy timing, but had different baseline characteristics ),” the authors write.